Mitochondrial disease in flies

Flies in Relation to Disease

Smith, m.d. Cambridge Public Health Series: University Press, 1913. This is one of the earliest volumes of the new Public Health Series issued by the Cambridge University Press. If the otber volumes promised reach the high level of the present one the series will bo remarkable and successful. The present volume, by Dr. Graham Smith, the University Lecturer in Hygiene, and one of the general edi...

Flies and Disease

Human mitochondrial disease-like symptoms caused by a reduced tRNA aminoacylation activity in flies

The translation of genes encoded in the mitochondrial genome requires specific machinery that functions in the organelle. Among the many mutations linked to human disease that affect mitochondrial translation, several are localized to nuclear genes coding for mitochondrial aminoacyl-transfer RNA synthetases. The molecular significance of these mutations is poorly understood, but it is expected ...

mitochondrial disease

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Flies as models of disease

By all appearances flies and humans are quite different. Nevertheless, their genetics and underlying DNA sequences are remarkably similar. Many human disease genes have sequences common with those in Drosophila (Bier, 2005). This genetic similarity supports the notion that basic research in Drosophila will accelerate translational research for a wide range of diseases. Disease-orientated Drosop...